Candice Afia

Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns.

The residents and interns treat the victims of a massive explosion at an apartment building; Mama Burke returns to collect her son's things; Lexie tries to have a heart-to-heart with unwilling Meredith.

Cristina and Burke's wedding day arrives; the interns get their exam results; Callie and George make a decision about their relationship.

George's skill level dazzles the new interns; Meredith half-heartedly helps Lexie with her first emergency patient.

Addison, Naomi and Sam rush Archer to Seattle Grace, where they reunite with old friends in hope of saving his life; Izzie devises a medical game to teach the interns; Owen runs into someone significant from his past.

Meredith tries to convince Derek to come back to work; Mark attempts a face transplant surgery; Izzie tries to keep her medical condition a secret.