Patti Murin

Doctors Manning and Rhodes suspect that two separate cases involving sick babies may be connected. A homeless patient's upbeat disposition enlightens Doctors Halstead and Charles, and Dr Choi and a Navy corpsman deal with the toll of gang violence.

Family secrets bubble up to the surface when Maggie's sibling arrives back in town. Dr Manning works on a case that is getting lost in translation.

A car crash at the Chicago Marathon leaves victims in critical condition, and April and her medical resident brother must perform an operation in the field. An 8-year-old girl experiences sudden hearing loss, and Dr Choi treats a malnourished woman.

Dr Rhodes is tasked with delivering some devastating news. April suffers an accident and Dr Halstead presses her into seeking treatment.

Dr Charles' daughter joins the epidemiology department and is immediately put to task when cases of a rare infection are discovered.

The team treats a 9/11 hero in need of new lungs. Dr Choi deals with a difficult parent. There's friction between Dr Halstead and Dr Manning.