Theo Breaux

When Dr. Alicia Seberg, a government research scientist (guest star Amy Price-Francis), is exposed to a deadly toxin while at work and has only hours to live, she calls Patrick Jane and the CBI to find her murderer.

Residency Director Dr. Leanne Rorish (Marcia Gay Harden) puts her four new first year residents to work immediately on their first day at Angels Memorial Hospital, in the busiest, most notorious hospital ER in the nation.

A plane crashes into the eighth floor of the hospital; when Noa is in a car accident, it is up to Mario to save her life; Willis admits to Rox that he needs her in his life; the doctors gather in court to support Leanne for her custody hearing.

Neal clashes with his father, Dr. Peter Hudson, who is a neurosurgeon, over how to treat his gravely ill mother, Asra Hudson, whose mysterious symptoms force Angels Memorial to quarantine Trauma One.

Christa must put aside her personal feelings for Grace and work with her to treat Brody, , a patient who claims to have been abused at a camp for troubled teens. Also, Grace is surprised when Campbell asks her out.

Max is brought to Angels Memorial with breathing difficulty; Willis decides to get to the bottom of what happened to his brother's unit.