Candice Afia

An ambulance crash endangers the lives of the paramedics involved, as Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help.

Addison, Naomi and Sam rush Archer to Seattle Grace to try and save his life; Owen runs into a significant someone from his past; Izzie employs her fellow doctors in a medical game to teach the interns.

Derek prepares to perform his first surgery since his breakdown; Owen has a PTSD episode which injures Cristina and puts their relationship in jeopardy.

Derek's mother arrives in Seattle and meets Meredith for the first time; the patient on death row wants to donate his organs to Bailey's young patient, Jackson; Callie has a patient who had surgery to make him taller, only it caused massive infections in his legs; Owen asks Cristina out on a date.

Cristina tells Alex and Bailey about Izzie's condition; Mark is doing a face transplant on a patient and Owen and Alex are the donor gathering team; Bailey sends Callie after Derek to bring him back and Callie ends up staying in his vortex of self-pity.

Cristina and Burke's wedding day arrives - along with the interns' first exam results - and a successor to the Chief is named, as Callie and George make a big decision about their relationship.